| CatalogCode: | NB110-57148 |
| ProductName: | Kv4.2 Antibody |
| Product Description: | Rabbit Monoclonal anti-Kv4.2 (EP982Y) |
| Clone: | EP982Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human Kv4.2 was used as an immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1000IHC: 1:100 - 250FC: 1:30 |
| Background: | Kv4.2, a voltage-gated K+ (Kv) channel subunit, has been suggested to be the key component of the subthreshold A-type K+ currents (I(SA)s) recorded from the specific subcellular compartments of certain CNS neurons (1). A-type channels, encoded by the pore-forming alpha-subunits of the Kv4.x family, are particularly important in regulating membrane excitability in the CNS and the heart. Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus (2). Deletion of the Kv4.2 gene and a loss of Kv4.2 protein resulted in a specific and near-complete elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons. The absence of dendritic Kv4.2-encoded A-type K+ currents led to an increase of bAP amplitude and an increase of concurrent Ca2+ influx (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Tsaur ML, et al. Chin J Physiol 44(3):133-14, 2001 2. Adams JP, et al. J Neurochem. 75(6):2277-87, 2000 3. Chen X, et al. J Neurosci 26(47):12143-51, 2006 |
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