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| Catalog Code: | NB110-57147 |
| Product Name: | Ki-67 Antibody |
| Product Description: | Rabbit Monoclonal anti-Ki-67 (SP6) |
| Clone: | SP6 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | A synthetic peptide from C terminus of human Ki67. |
| Specificity: | A synthetic peptide from C-terminus of human Ki-67. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Background: | Ki-67 antigen is a nuclear antigen specifically associated with cell proliferation. Ki-67 is expressed in all proliferating cells which are in the active phases of the cell cycle (late G1, S, G2, and mitosis), but absent in resting cells. In G1, it is predominately localized in the perinucleolar region and also found in nuclear matrix in the later phases (1). Ki-67 is thought to be involved in the maintaining of cell proliferation, however, its exact mechanism for function is unknown. Due to the fact that Ki-67 can be used to determine the growth fraction (the proportion of the cells committed to the cell cycle), it is consider an important marker in human tumor diagnostics and prognostics (2). |
| Storage: | Store at 2-8 degrees C. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 0.05% BSA. |
| Application Summary: | immunohistochemistry 1/200 |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Antigen identified by monoclonal antibody, anti-Ki 67 antibody, anti-Antigen KI67 antibody, anti-KIA antibody, anti-MKI67 antibody, anti-Proliferation related Ki 67 antigen antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.1% sodium azide |
| General References: | 1. Gerdes J Semin Cancer Biol 1(3):199-206, 1990. 2. Gerdes J, Scholzen T J Cell Physiol 182(3):311-322, 2000. |
| Product References: | Immunomorphological assessment of the new Ki-67 specific rabbit monoclonal SP6 antibody on fixed-embedded tissue sections. R Keszthelyi R, Zs Halas, H. Xia, Gy Szekeres. Pathology Oncology Research 2004. |
| Novus References: | 1. Popa I, Zubkova I, Medvedovic M, et al. Regeneration of the adult thymus is preceded by the expansion of K5+K8+ epithelial cell progenitors and by increased expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma. Int Immunol. 2007 November 1, 2007;19(11):1249-60. |
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