| CatalogCode: | NB110-57146 |
| ProductName: | JAM1 (N-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-JAM1 (N-term) (EP1042Y) |
| Clone: | EP1042Y |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide corresponding to residues near the N-terminus of human Junctional Adhesion Molecule 1. |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human JAM1 was used as an immunogen. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:2000IHC: 1:100 - 250 |
| Background: | Junctional Adhesion Molecules (JAMs) are components and regulators of the well-characterized epithelial and endothelial tight junction. JAM is selectively concentrated at intercellular junctions of endothelial and epithelial cells of different origins. Microscopy shows that JAM codistributes with tight junction components at the apical region of the intercellular cleft. A mAb directed to JAM (BV11) was found to inhibit spontaneous and chemokine-induced monocyte transmigration through an endothelial cell monolayer in vitro. Systemic treatment of mice with BV11 mAb blocked monocyte infiltration upon chemokine administration in subcutaneous air pouches (1). The human protein shares a highly conserved structure and sequence with the murine protein. However it is distinct in that it is constitutively expressed on circulating neutrophils, monocytes, platelets and lymphocyte subsets (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-CD321 antibody, anti-CD 321 antibody, anti-CD321 antigen antibody, anti-F11 receptor antibody, anti-F11R antibody, anti-JAM 1 antibody, anti-JAM A antibody, anti-JAM antibody, anti-JAM1 antibody, anti-JAMA antibody, anti-JCAM anti-antibody, anti-Junctional adhesion molecule A antibody, anti-KAT antibody, anti-PAM 1 antibody, anti-PAM1 antibody, anti-Platelet adhesion molecule 1 antibody, anti-Platelet adhesion molecule antibody, anti-Platelet F11 receptor antibody, anti-UNQ264/PRO301 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Martin-Padura I, et al. J Cell Biol 142(1):117-27, 1998 2. Williams LA, et al. Mol Immunol 36(17):1175-88. |
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