| CatalogCode: | NB110-57144 |
| ProductName: | Phospho-Jak2 (pY1007/1008) Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho-Jak2 (pY1007/1008) (E132) [Tyr1007/Tyr1008] |
| Clone: | E132 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Tyr 1007 and Tyr 1008 of human JAK2 |
| Specificity: | A synthetic phospho-peptide corresponding to residues surrounding Tyr1007 and Tyr1008 of human JAK2 was used as immunogen. The antibody only detects JAK2 phosphorylated on Tyrosine 1007 and 1008. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml IgG purified Rabbit ascites. |
| Uses: | WB: 1:5,000-10,000IHC: 1:50-100ICC: 1:50-100IP: 1:50 |
| Background: | Jak2 is a member of the Janus family tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the signal transducers and activators of transcription (STATs). Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Tyr1007/1008 of Jak2 are the homologous Tyr1054/1055 in Tyk2, and phosphorylation at these residues is needed for Tyk2 activation (3). A chromosomal aberration involving Jak2 is found in a form of pre-B acute myeloid leukemia (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-JAK 2 antibody, anti-Janus Activating Kinase 2 antibody, anti-Janus Kinase 2 antibody, anti-OTTHUMP00000043260 antibody, anti-Tyrosine protein kinase JAK2 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Leonard, W.J. and J.J. O'Shea. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16: 293-332 (1998). 2. O'Shea, J.J., et al. Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency. J Clin Immunol. 17: 431-47 (1997). 3. Gauzzi, M.C., et al. Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J. Biol. Chem. 271: 20494-20500 (1996). |
| Phosphorylated: | Tyr1007/Tyr1008 |
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