| CatalogCode: | NB110-57137 |
| ProductName: | Phospho IRS-1 (pY896) Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho IRS-1 (pY896) (EP260Y) [Tyr896] |
| Clone: | EP260Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human IRS-1was used as immunogen. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:500,000 |
| Background: | Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulators of IR and the insulin-like growth factor-1 receptor. Disruption of IRS-1 causes growth retardation and insulin resistance associated with hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation (4-5) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | HIRS 1 antibody HIRS1 antibody Insulin Receptor Substrate 1 antibody IRS 1 antibody anti-IRS1 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Sun XJ, et al. Nature. 352:73-77, 1991 2. White MF. Diabetologia. 40:S2-S17, 1997 3. Virkamaki, A., et al. J. Clin. Investig. 103, 931-943, 1999 4. Araki E, et al. Nature. 372:186-190, 1994 5. Abe H, et al. J Clin Invest. 101:1784-1788, 1988 |
| Phosphorylated: | Tyr896 |
|