| request information: |
|
| Catalog Code: | NB110-57126 |
| Product Name: | IRAK-3 (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-IRAK-3 (C-term) (Y278) |
| Clone: | Y278 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in the C-term of human IRAK-3 was used as immunogen. |
| Cross Reactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1: 20,000IP: 1:50 |
| Background: | IRAK-3 (also known as IRAK-M) is a member of the interleukine-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon stimulation, IRAK gets phosphorylated and activates NF-kB (2). Unlike IRAK, IRAK2 and IRAK4 which are expressed ubiquitously, IRAK-3 is mostly expressed in monocytes and macrophages (3). IRAK-M and IRAK-2 lack kinase activity, while IRAK-3 has a weak capacity to be phosphorylated. Additionally, IRAK-3 has been found to negatively regulate TRL signaling to protect from endotoxic shock (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu, Rt(-), |
| Alternate Names: | anti-IL 1 receptor associated kinase M antibody, anti-IL1 receptor associated kinase M antibody, anti-Interleukin 1 receptor associated kinase 3 antibody, anti-Interleukin 1 receptor associated kinase M antibody, anti-IRAK 3 antibody, anti-IRAK M antibody, anti-IRAK3 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Cao, Z., W. J. Henzel, X. Gao. 1996. Science 271:11282. 2. Kanakaraj, P., K. Ngo, Y. Wu, A. Angulo, P. Ghazal, C. A. Harris, J. J. Siekierka, P. A. Peterson, W. P. Fung-Leung. 1999. J. Exp. Med. 189:1129 3. H., Gao, X., Li, X., Kirschning, C.J., Stark, G.R. and Cao, Z., 1999. J. Biol. Chem. 274, pp. 19403-19410. 4. Muzio, M., Ni, J., Feng, P. and Dixit, V.M., 1997. Science 278, pp. 1612-1615. 5. Koichi Kobayashi, Lorraine D. Hernandez, Jorge E. Galán, Charles A. Janeway, Jr, Ruslan Medzhitov and Richard A. Flavell. Cell, Volume 110, Issue 2 , 26 July 2002, Pages 191-202 |
order or
more information: | company product webpage |
|