| CatalogCode: | NB110-57117 |
| ProductName: | IL-18BP Antibody |
| Product Description: | Rabbit Monoclonal anti-IL-18BP (EP1088Y) |
| Clone: | EP1088Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human IL18BP was used as an immunogen. |
| CrossReactivity: | Reacts in human and rat. Does not react in Mouse. Not tested in other species. |
| Packaging: | 0.1 ml Whole antisera Rabbit ascites. |
| Uses: | WB: 1:500IHC: 1:50 - 100FC: 1:10 |
| Background: | IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, WB |
| SpeciesSummary: | Hu, Mu(-), Rt |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Nicklin MJ, et al. Genomics 79, 718-725, 2002. 2. Nakanishi K, et al. Annu. Rev. Immunol. 19, 423-474, 2001 3. Aizawa Y, et al. FEBS Lett. 445(2-3):338-42, 1999. 4. Meng X, et al. Virology 358(1):211-20, 2007. |
|