| CatalogCode: | NB110-57116 |
| ProductName: | IL-17 Antibody |
| Product Description: | Rabbit Monoclonal anti-IL-17 (EP434Y) |
| Clone: | EP434Y |
| Clonality: | Monoclonal |
| Specificity: | A recombinant human IL-17 was used an immunogen. |
| CrossReactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1,000-5,000 (approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane) |
| Background: | Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by TCRá/â+ CD4 CD8 thymocytes, as well as by activated CD4+ and CD4+ CD45RO+ memory T cells (1). IL-17 stimulates the expression of TNFalpha, IL-1 beta, IL-6, and IL-8 (2). In addition, IL-17 is involved in the induction of inducible nitric oxide synthase and cyclooxygenase 2 in chondrocytes (3). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt(-) |
| ALTnames: | CTLA 8 antibody CTLA8 antibody Cytotoxic T lymphocyte associated antigen 8 antibody Cytotoxic T lymphocyte associated protein 8 antibody Cytotoxic T lymphocyte associated serine esterase 8 antibody IL 17A antibody IL17A antibody Interleukin 17 antibody Interleukin 17A antibody Interleukin17 antibody Interleukin17A antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Yao, Z. , Painter, S. L. , Fanslow, W. C. , Ulrich, D. , Macduff, B. M. , Spriggs, M. K. & Armitage, R. J. (1995) J. Immunol. 155, 5483-5486 2. Fossiez, F. , Banchereau, J. , Murray, R. , Van Kooten, C. , Garrone, P. & Lebecque, S. (1998) Int. Rev. Immunol. 16, 541-551 3. Shalom-Barak, T. , Quach, J. & Lotz, M. (1998) J. Biol. Chem. 273, 27467-27473 4. Ziolkowska, M. , Koc, A. , Luszczykiewicz, G. , Ksiezopolska-Pietrzak, K. , Klimczak, E. , Chwalinska-Sadowska, H. & Maslinski, W. (2000) J. Immunol. 164, 2832-2838 |
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