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| Catalog Code: | NB110-57115 |
| Product Name: | IL-15 Antibody |
| Product Description: | Rabbit Monoclonal anti-IL-15 (EP433Y) |
| Clone: | EP433Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A recombinant human IL-15 was used an immunogen. |
| Cross Reactivity: | Reacts in human. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1,000-5,000 (approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane) |
| Background: | Interleukin 15 (IL-15) is a cytokine that shares many biological activities with IL-2. Both cytokines interact with the â and ã component of the IL-2 receptor. However, unlike IL-2 which is secreted only by T cells, IL-15 is expressed preferentially by nonlymphoid tissues, epithelial, and fibroblast cell lines (1). Two isoforms of human IL-15 are known. The longer form is localized to the plasma membrane or may be secreted, while the other (the shorter form) is found within the cytoplasm and the nucleus (2). IL-15 regulates T and natural killer cell activation and proliferation, causes B cell proliferation and differentiation and stimulates chemotaxis of T cells (3-4). It also induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. High concentrations of IL-15 have been observed in inflamed joints of rheumatoid arthritis patients, suggesting a role for IL-15 in inflammatory diseases where there is recruitment of leukocytes (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-IL 15 antibody, anti-Interleukin 15 antibody, anti-Interleukin15 antibody, anti-MGC9721 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D, EMBO J 13:2822, 1994 2. Gaggero, A., B. Azzoarone, C. Andrei, A. Mishal, R. Meazza, E. Zappia, A. Rubertelli, S. Ferrini. 1999. Eur. J. Immunol. 29:1265. 3. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH, J Immunol 154:483, 1995 4. Wilkinson PC, Liew FY: Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181:1255, 1995 |
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