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| Catalog Code: | NB110-57114 |
| Product Name: | IL-10 Antibody |
| Product Description: | Rabbit Monoclonal anti-IL-10 (EP1115Y) |
| Clone: | EP1115Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide (Human) |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human IL-10 was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:5000 |
| Background: | Interleukin (IL)-10 is a cytokine that inhibits production of other regulatory factors, including interferon gamma (IFN-gamma) and IL-2. A dimer of IL-10 is present in solution and is presumed to participate in receptor binding (1). IL-10 is a natural endogenous immunosuppressive cytokine that has been identified in human, murine, and other organisms. Human IL-10 (hIL-10) has high homology with murine IL-10 (mIL-10) as well as with an Epstein-Barr virus genome product BCRFI (2). IL-10 displays pleiotropic immunoregulatory properties. Human and murine IL-10 have a high amino acid sequence identity (ca. 73%) which includes the conservation of all four cysteine residues in human IL-10 and the first four out of five cysteine residues for murine IL-10. IL-10 is a highly alpha-helical protein containing two disulfide bonds, either one or both of which are critical for its structure and function (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-CSIF antibody, anti-Cytokine Synthesis Inhibitory Factor antibody, anti-IL 10 antibody, anti-IL10A antibody, anti-Interleukin 10 antibody, anti-Interleukin10 antibody, anti-MGC126450 antibody, anti-MGC126451 antibody, anti-TGIF antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Windsor WT, et al. Biochemistry 32(34):8807-15, 1993. 2. Gesser B, et al. Proc Natl Acad Sci 94(26):14620-5, 1997. 3. Zdanov A, et al. Structure 3(6):591-601, 1995. |
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