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| Catalog Code: | NB110-57112 |
| Product Name: | IL-1 Beta Antibody |
| Product Description: | Rabbit Monoclonal anti-IL-1 Beta (EP407Y) |
| Clone: | EP407Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A recombinant human IL-1 beta protein was used as an immunogen. |
| Cross Reactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:20,000 (approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane) |
| Background: | Interleukin 1 beta (IL1 beta) is a pro-inflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursors. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. Recent studies have shown IL1 beta to be a major cause of severe inflammation in the mouse model of Crohn's disease, implicating IL1 beta as a potential marker for this disease (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-Catabolin antibody, anti-H1 antibody, anti-Hematopoietin 1 antibody, anti-IFN beta inducing factor antibody, anti-IL 1 antibody, anti-IL 1 beta antibody, anti-IL 1B antibody, anti-IL1B antibody, anti-IL1F2 antibody, anti-Interleukin 1 beta antibody, anti-Interleukin 1 beta precursor antibody, anti-LAF antibody, anti-OAF antibody, anti-Osteoclast activating factor antibody, anti-Preinterleukin beta antibody, anti-Pro interleukin 1 beta antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. March CJ, et al. Nature 315:641-647, 1985. 2. Dinarello CA, et al. Blood 87:2095-2147, 1996. 3. Yuan J, et al. Cell 75:641-652, 1993 4. Shin M, et al. Science 4:734-738, 2005. |
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