| CatalogCode: | NB110-57111 |
| ProductName: | IKK-beta Antibody |
| Product Description: | Rabbit Monoclonal anti-IKK-beta (Y466) |
| Clone: | Y466 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-term of human IKK-beta was used as immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1: 1,000-5,000IHC: 1:50-100Flow Cytometry: 1:40IP: 1: 50 |
| Background: | IKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta (3). Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response (4). Additionally, IKK-beta activity can also be regulated by MEKK-1 (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.5% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, IP, WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | I kappa B kinase 2 antibody I kappa B kinase beta antibody IkBKB antibody IKK 2 antibody IKK B antibody IKK2 antibody IKKB antibody Inhibitor of kappa light chain gene enhancer in B cells antibody Inhibitor of kappa light polypeptide gene enhancer in B cells antibody Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta antibody Inhibitor of nuclear factor kappa B kinase beta subunit antibody Inhibitor of nuclear factor kappa B kinase subunit beta antibody MGC131801 antibody NFKBIKB antibody Nuclear factor NF kappa B inhibitor kinase beta antibody Nuclear factor of kappa light chain gene enhancer in B cells inhibitor antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Zandi, E.; Rothwarf, D. M.; Delhase, M.; Hayakawa, M.; Karin, M.: Cell 91: 243-252, 1997 2. Scheidereit, C. Docking IB kinase. Nature 395: 225-226, 1998 3. Woronicz, J. D.; Gao, X.; Cao, Z.; Rothe, M.; Goeddel, D. V.: Science 278: 866-869, 1997. 4. Delhase, M.; Hayakawa, M.; Chen, Y.; Karin, M.: Science 284: 309-312, 1999. 5. Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. Proc. Natl. Acad. Sci. USA 95: 3537-3542, 1998 |
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