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| Catalog Code: | NB110-57108 |
| Product Name: | IFN-gamma Antibody |
| Product Description: | Rabbit Monoclonal anti-IFN-gamma (EP1109Y) |
| Clone: | EP1109Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues human IFN-ã was used as an immunogen. |
| Cross Reactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:2,000 |
| Background: | Interferons (IFNs) plays a crucial role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. In particular, Interferon gamma (IFN-ã), a sole member of Type II IFN family, is involved in the lymphocyte activation and the regulation of lymphocyte subsets (proliferation, differentiation) (1). IFN-ã is expressed in activated CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. IFN-ã expression is induced by IL-2, TNF-á and IL-12 and suppressed by IL-4, IL-10, and TGF-â (2). IFN-ã binds to IFN-ã receptor (IFNGR) which stimulates various immuno-responses, such as macrophages activation and enhancement of the type I IFNs anti-viral and anti-tumor activities. In immunocompetent host cells, IFN-ã protects against tumor development and directs immunogenic phenotype (3). IFN-ã has been implicated various human diseases, such as multiple sclerosis and insulin-dependent diabetes mellitus (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-IFNG antibody, anti-IFG antibody, anti-IFI antibody, anti-IFN gamma antibody, anti-IFN immune antibody, anti-Immune interferon antibody, anti-Interferon gamma precursor antibody, anti-Macrophage activating factor antibody, anti-MAF antibody, anti-T Cell interferon antibody, anti-Type II Interferon antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Bach EA et al. Annu. Rev. Immunol. 15;563-591, 1997. 2. Sen, GC et al. Viruses and interferons Annu. Rev. Microbiol. 55:255 3. Schroder K et al. Journal of Leukocyte Biology, 75:163-189, 2004. 4. Panitch HS et al. Lancet 1,893-895, 1987. |
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