| CatalogCode: | NB110-57064 |
| ProductName: | Hsp70 (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-Hsp70 (C-term) (EP1007Y) |
| Clone: | EP1007Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-term of human Hsp70 was used as an immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:20,000IHC: 1:50 - 100FC: 1:10IP: 1:50 |
| Background: | The 70-kDa Heat Shock Protein (Hsp70) is a highly conserved member of the molecular chaperone network commonly found in nuclear, cytosolic, mitochondrial and endoplasmic reticulum compartments of all eukaryotic and prokaryotic cells. Hsp70 uses ATP binding and hydrolysis to assist in efficient folding of both newly created and stress-denatured polypeptides. (1). Under environmental stress conditions, synthesis of Hsp70 is quickly up-regulated and redistributed throughout the cell. (2). It has been shown that Hsp70 has the ability to bind with high affinity to the plasma membrane, activate NF-KappaB and also up-regulate expression of pro-inflammatory cytokines tumor necrosis factor (TNF)-á, interleukin (IL)-1â and IL-6 in human monocytes (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, IP, WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Yam AY, et al. J Biol Chem 50:41252-61, 2005 2. Prohaszka Z, et al. Cell Stress Chaperones 1:17-22, 2002 3. Asea A. J Biol Chem 17:15028-34, 2002 |
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