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| Catalog Code: | NB110-57063 |
| Product Name: | Hsp60 Antibody |
| Product Description: | Rabbit Monoclonal anti-Hsp60 (EP1006Y) |
| Clone: | EP1006Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide corresponding to residues in the internal region of human Hsp60. |
| Specificity: | A synthetic peptide corresponding to residues in the internal region of human Hsp60 was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:5000IHC: 1:100-250 |
| Background: | The 60-kDa Heat Shock Protein (Hsp60) is a highly conserved member of the molecular chaperone network commonly imported into the mitochondria to assist in the folding and assembly of mitochondrial proteins (1). Under environmental stress conditions, synthesis of Hsp60 is up-regulated then involved in gene expression regulation, DNA replication, signal transduction, differentiation, apoptosis, cellular senescence or immortalization (2). Hsp60 is also believed to protect mitochondrial ATPase activity under conditions of increasing temperature (3). Hsp60, along with Hsp70, has also been shown to play a role in a danger signalling cascade in response to bacterial infection (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry , Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-60 kDa heat shock protein mitochondrial antibody, anti-Chaperonin antibody, anti-CPN 60 antibody, anti-CPN60 antibody, anti-GROEL antibody, anti-GroEL Homolog antibody, anti-Heat shock 60kD protein 1 chaperonin antibody, anti-Heat shock 60kDa protein 1 antibody, anti-Heat Shock Protein 60 antibody, anti-Heat shock protein 65 antibody, anti-Hsp 60 antibody, anti-HSP 65 antibody, anti-HSP65 antibody, anti-HSPD 1 antibody, anti-HSPD1 antibody, anti-HuCHA60 antibody, anti-Mitochondrial matrix protein P1 antibody, anti-P60 lymphocyte protein antibody, anti-Short heat shock protein 60 Hsp60s1 antibody, anti-Spastic paraplegia 13 antibody, anti-SPG 13 antibody, anti-SPG13 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Prasad YM, et al. Mol Cell Biol (8):3979-86, 1990 2. Czarnecka AM, et al. Cancer Biol Ther. (7):714-20, 2006 3. Patriarca EJ, Exp Cell Res. (1):57-64, 1990 4. Davies EL, et al. Clin Exp Immunol. (1):183-9, 2006 |
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