| CatalogCode: | NB110-57056 |
| ProductName: | HPK1 (N-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-HPK1 (N-term) (EP630Y) |
| Clone: | EP630Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues in the N-term of human HPK1 was used as immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5,000-20,000IHC: 1:50-100Flow Cytometry: 1:60 |
| Background: | The hematopoietic progenitor kinase 1 (HPK1) is a mammalian hematopoiesis-specific Ste20 homologue belonging to the germinal center (GC) kinase family, which contains at least 20 kinases (1). HPK1 is implicated in a variety of signaling systems, including epidermal growth factor, transforming growth factor-beta, erythropoietin, prostaglandin E2, and T cell receptor and B cell receptor stimulation. HPK1 is also involved in Fas ligation-mediated apoptosis, NF-B activation and a highly specific activator of the JNK/SAP signaling pathway (2-5). Phosphorylation of HPK1 on threonine 165, serine 171 and tyrosine 379 is a prerequisite for its enzymatic activation in response to immunoreceptor stimulation (6). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-HPK1 antibody, anti-Human Hematopoietic Progenitor Kinase antibody, anti-MAPK/ERK kinase kinase kinase 1 antibody, anti-MEK kinase kinase 1 antibody, anti-MEKKK 1 antibody, anti-Mitogen Activated Protein Kinase Kinase Kinase Kinase 1 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Dan, I., N. M. Watanabe, and A. Kusumi. 2001. Trends Cell Biol. 11:220-230 2. Anafi, M., Kiefer, F., Gish, G. D., Mbamalu, G., Iscove, N. N., and Pawson, T. (1997) J. Biol. Chem. 272, 27804-27811 3. Wang, W., Zhou, G., Hu, M. C.-T., Yao, Z., and Tan, T.-H. (1997) J. Biol. Chem. 272, 22771-22775 4. Liu, S. K., Smith, C. A., Arnold, R., Kiefer, F., and McGlade, C. J. (2000) J. Immunol. 165, 1417-1426 5. Chen, Y.-R., Meyer, C. F., Ahmed, B., Yao, Z., and Tan, T.-H. (1999) Oncogene 18, 7370-7377 6. Tsuji et al. 2001. J. Exp. Med. 194:529-539 |
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