| CatalogCode: | NB110-57055 |
| ProductName: | hnRNP K Antibody |
| Product Description: | Rabbit Monoclonal anti-hnRNP K (EP943Y) |
| Clone: | EP943Y |
| Clonality: | Monoclonal |
| Immunogen: | A synthetic peptide corresponding to residues near the N-terminus of human hnRNP. |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human hnRNP was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated hnRNP K. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:100,000IHC: 1:100 - 250ICC: 1:100 - 250IP: 1:50 |
| Background: | The hnRNP-K family of acidic nuclear proteins has been identified using a monoclonal antibody that distinguishes between quiescent and proliferating human keratinocytes. The family, which is composed of four major proteins (hnRNPs-K A, B, C and D) and their modified forms, is present in similar overall levels in quiescent and proliferating normal keratinocytes although clear differences were observed in the levels of some of the individual variants (1). hnRNP-K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals (2). hnRNP-K has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis, for instance hnRNP K increases transcription of the oncogene c-myc and hnRNP K expression is regulated by the p53/MDM 2 pathway (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-dC stretch binding protein antibody, anti-FLJ41122 antibody, anti-Heterogeneous nuclear ribonucleoprotein K antibody, anti-hnRNP K antibody, anti-HNRNPK antibody, anti-HNRPK antibody, anti-Transformation up regulated nuclear protein antibody, anti-Transformation upregulated nuclear protein antibody, anti-TUNP antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Dejgaard K, et al. J Mol Biol. 236(1):33-48, 1994. 2. Mikula M, et al. Proteomics (8):2395-406, 2006. 3. Carpenter B, et al. Br J Cancer 95(7):921-7, 2006. |
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