| CatalogCode: | NB110-57036 |
| ProductName: | Histone H2A, Acetyl-K5 Antibody |
| Product Description: | Rabbit Monoclonal anti-Histone H2A, Acetyl-K5 (EP856Y) |
| Clone: | EP856Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human Histone H2A was used as an immunogen. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:100,000IHC: 1:250 - 500ICC: 1:500 - 1000IP: 1:70 |
| Background: | Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). It has been shown that DNA damage induces monoubiquitylation of histone H2A in the vicinity of DNA lesions. Ultraviolet -induced monoubiquitylation of H2A is dependent on functional nucleotide excision repair. It occurs after incision of the damaged strand and forms part of the cellular response to UV damage and suggests a role of this modification in DNA repair-induced chromatin remodeling (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-H2AFM antibody, anti-HIST1H2A antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Braunstein M, et al. Mol. Cell. Biol. 16:4349-56, 1996. 2. Workman JL, Kingston RE,. Annu. Rev. Biochem. 67: 545-579, 1998. 3. Bergink S, et al. Genes Dev. 20(10):1343-52, 2006. |
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