| CatalogCode: | NB110-57034 |
| ProductName: | Histone Deacetylase 4 Antibody |
| Product Description: | Rabbit Monoclonal anti-Histone Deacetylase 4 (Y416) |
| Clone: | Y416 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human Histone Deacetylase 4 was used as immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1,000-5,000ICC: 1:250-500 |
| Background: | Histone deacetylase 4 belongs to the histone deacetylase family type 2 which actively deacetylate the 4 core Histones . HDAC4 possesses two repression domains, one composed of the N-terminal 208 residues and the other consist of a deacetylase domain (1). The N-term will interact with the MADX-box of MEFC2 to negatively regulate expression. Additionally, the deacetylase activity of HDAC4 is subject to negative regulation by its N-terminal domain (2). HDAC4 is also implicated in the regulation of muscle differentiation. During muscle differentiation, HDC4 is shuttled between nuclear and cytoplasmic compartments. Phosphorylation by CAMK4 at S246, S467 and S632 can control HDAC4 subcellular localization (3-4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-HD 4 antibody, anti-HD4 antibody, anti-HDAC 4 antibody, anti-HDAC A antibody, anti-HDACA antibody, anti-Histone Deacetylase 4 antibody, anti-Histone Deacetylase A antibody, anti-KIAA0288 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Grunstein, M. 1997. Nature 389:349-352 2. Miska, E., C. Karlsson, E. Langley, S. Nielsen, J. Pines, and T. Kouzarides. EMBO J., in press 3. Lu, J., McKinsey, T. A., Nicol, R. L., and Olson, E. N. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4070-4075 4. Xuan Zhao, Akihiro Ito, Christopher D. Kane, Ting-Sheng Liao, Timothy A. Bolger, Shannon M. Lemrow, Anthony R. Means, and Tso-Pang Yao, J. Biol. Chem., Vol. 276, Issue 37, 35042-35048, September 14, 2001 |
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