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| Catalog Code: | NB110-57026 |
| Product Name: | erbB4/HER4 (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-erbB4/HER4 (C-term) (E200) |
| Clone: | E200 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to C-terminus (cytoplasmic domain) of human ErbB4 was used as immunogen. The antibody does not cross-react with other EGF receptor family members. |
| Cross Reactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:4,000ICC: 1:50Flow Cytometry : 1:40IP: 1:100 |
| Background: | erbB4/HER4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt(-), |
| Alternate Names: | anti-Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody, anti-ErbB4 antibody, anti-HER 4 antibody, anti-HER4 antibody, anti-MGC138404 antibody, anti-P180erbB4 antibody, anti-Receptor protein tyrosine kinase erbB 4 precursor antibody, anti-Receptor tyrosine protein kinase erbB 4 antibody, anti-Tyrosine kinase type cell surface receptor HER4 antibody, anti-v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody, anti-v erb a erythroblastic leukemia viral oncogene homolog 4 antibody, anti-Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody, anti-Verba erythroblastic leukemia viral oncogene homolog 4 antibody, anti-VERBB2 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Plowman, G.D., et al. Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci U S A. 90: 1746-50 (1993). 2. Elenius, K., et al. A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem. 272: 26761-8 (1997). 3. Garcia, R.A., et al. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci U S A. 97: 3596-601 (2000). |
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