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| Catalog Code: | NB110-57016 |
| Product Name: | GSK3 alpha Antibody |
| Product Description: | Rabbit Monoclonal anti-GSK3 alpha (EP793Y) |
| Clone: | EP793Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminal residues of human GSK3-á was used as an immunogen. |
| Cross Reactivity: | Reacts in human and rat. Does not react in mouse. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5000IHC: 1:50 - 100ICC: 1:50 - 100IP: 1:50 |
| Background: | Glycogen synthases kinase 3 alpha (GSK3-á) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-á activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-á by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-á activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt, |
| Alternate Names: | anti-DKFZp686D0638 antibody, anti-Glycogen synthase kinase 3 alpha antibody, anti-GSK 3 alpha antibody, anti-GSK 3A antibody, anti-GSK3A antibody, anti-GSK3alpha antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Martinho RG, et al. EMBO J. 17:7239-7249, 1998. 2. Cross DA, et al. Nature 378:785-789, 1995. 3. Sanchez Y, et al. Science 277:1497-1501, 1997. 4. Lovestone S, et al. Curr Biol 4(12):1077-1086, 1994. |
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