| CatalogCode: | NB110-57014 |
| ProductName: | GRB2 (N-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-GRB2 (N-term) (Y301) |
| Clone: | Y301 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues in the N-terminus of human GRB2 was used as an immunogen. This antibody can also detect the splice isoform GRB3-3 of GRB2. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1,000-2,000IHC: 1:100-250ICC: 1:100-250FC: 1:40 |
| Background: | The growth factor bound protein 2 (GRB2) is a 25 kDa cytosolic protein that contains one src homology (SH2) domain and two SH3 domains (1). GRB2 associates with Tyrosine phosphorylated EGFRs and PDGFRs via its SH2 domain. GRB2 also plays a crucial role in two separate insulin pathways leading from the insulin receptor to the Ras protein thus affecting mitogenic signaling (2). Additionally GBR2, a bifunctional adaptor protein, recruits Sos for Ras activation and subsequent signal transmission (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Adapter protein GRB2 antibody, anti-ASH antibody, anti-Ash protein antibody, anti-EGFRBP GRB2 antibody, anti-Epidermal growth factor receptor binding protein antibody, anti-Epidermal growth factor receptor binding protein GRB2 antibody, anti-GRB 2 antibody, anti-GRB2 adapter protein antibody, anti-Grb3 3 antibody, anti-Growth Factor Receptor Bound Protein 2 antibody, anti-Growth factor receptor bound protein 3 antibody, anti-HT027 antibody, anti-MST084 antibody, anti-MSTP084 antibody, anti-Protein ASH antibody, anti-SEM5 antibody, anti-SH2/SH3 adapter GRB2 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Matuoka, K.; Shibata, M.; Yamakawa, A.; Takenawa, T.: Proc. Nat. Acad. Sci. 89: 9015-9019, 1992 2. Lowenstein, E. J.; Daly, R. J.; Batzer, A. G.; Li, W.; Margolis, B.; Lammers, R.; Ullrich, A.; Skolnik, E. Y.; Bar-Sagi, D.; Schlessinger, J.: Cell 70: 431-442, 1992. 3. Nioche P.; et al, JMB, Volume 315, Number 5, February (2002), 1167-1177(11) |
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