| CatalogCode: | NB110-57012 |
| ProductName: | Golgi Matrix Protein (GM130) Antibody |
| Product Description: | Rabbit Monoclonal anti-Golgi Matrix Protein (GM130) (EP892Y) |
| Clone: | EP892Y |
| Clonality: | Monoclonal |
| Immunogen: | A synthetic peptide corresponding to residues near the N-term of human GM130. |
| Specificity: | A synthetic peptide corresponding to residues near the N-term of human Golgi Matrix Protein (GM130) was used as a immunogen. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody works for ICC, IHC, IP, WB (Detects a band of approximately 140 kDa (predicted molecular weight: 112 kDa)) and is unsuitable for FACS. |
| Control: | Peripheral membrane protein associated with Golgi stacks |
| Background: | Golgi Matrix Protein (GM130) is peripheral cytoplamic protein that is bound to the Golgi membranes. It has been implicated as a maintainer of cis-Golgi structure (1). During mitosis, it regulates the disassembly and reassembly of the Golgi complex. It is also linked to docking and fusion of coatomer (COP I) coated vesicles to the Golgi membrane (2). The COOH-terminal domain of GM130 is highly homologous to Golgi human auto-antigen, golgin-95. GM130 interacts specifically and GTP-dependent manner with Rab1b protein, a regulator of anterograde traffic between ER and Golgi membranes (3). GM130 is also activator of YSK1, an essential player in cell migration. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl, 40% Glycerol, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BS |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-GM130 autoantigen antibody, anti-GOLGA 2 antibody, anti-GOLGA2 antibody, anti-Golgi autoantigen antibody, anti-Golgi autoantigen golgin subfamily a 2 antibody, anti-Golgi matrix protein GM130 antibody, anti-Golgin 95 antibody, anti-Golgin subfamily a 2 antibody, anti-Golgin subfamily A member 2 antibody, anti-MGC20672 antibody, anti-SY11 protein antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Nakamura N, et al. J Cell Biol 131:1715-1726, 1995 2. Warren G, Annual Rev Biochem 62:323-348, 1993 3. Weide T, et al. EMBO Rep 2:336-341, 2001 |
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