| CatalogCode: | NB110-57011 |
| ProductName: | Phospho Glycogen Synthase (pS641) Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho Glycogen Synthase (pS641) (EP852Y) [Ser641] |
| Clone: | EP852Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic phospho-peptide corresponding to residues surrounding Ser641 of human Glycogen Synthase was used as immunogen. The antibody only detects Glycogen Synthase phosphorylated on Serine 641. |
| CrossReactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:10,000IHC: 1:100 - 250ICC: 1:50 - 100IP: 1:60 |
| Background: | Glycogen synthase is an enzyme of the transferase class that catalyses the reaction of UDP-glucose and (1,4-á-D-glucosyl)n to yield UDP and (1,4-á-D-glucosyl)n+1 (1-2). This tetrameric enzyme is the rate-limiting step for glycogen synthesis (3). Glycogen concentrations are regulated by the complementary activities of glycogen phosphorylase and glycogen synthase. Glycogen synthase activity is regulated by phosphorylation of serine residues and by insulin stimulation (4). Glycogen synthase is known to have two forms; the unphosphorylated and most active form, synthase-a, and the phosphorylated glucose-6-phosphate-dependent form, synthase-b. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt(-) |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Browner MF, et al. Proc Nat Acad Sci 86:1443-1447, 1989. 2. Skurat A, et al. Diabetes Mellitus, pp 213-222. 1996. 3. Hardy TA, et al. J Biol Chem 268:23799-23805, 1993. 4. Skurat AV, et al. J Biol Chem 269:25534-25542, 1994. |
| Phosphorylated: | Ser641 |
|