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| Catalog Code: | NB110-57009 |
| Product Name: | Glycogen Synthase Antibody |
| Product Description: | Rabbit Monoclonal anti-Glycogen Synthase (EP816Y) |
| Clone: | EP816Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of the human glycogen synthase was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:20,000IHC 1:250 - 500ICC: 1:100 - 250IP: 1:50 |
| Background: | Glycogen synthase is an enzyme of the transferase class that catalyses the reaction of UDP-glucose and (1,4-á-D-glucosyl)n to yield UDP and (1,4-á-D-glucosyl)n+1 (1-2). This tetrameric enzyme is the rate-limiting step for glycogen synthesis (3). Glycogen concentrations are regulated by the complementary activities of glycogen phosphorylase and glycogen synthase. Glycogen synthase activity is regulated by phosphorylation of serine residues and by insulin stimulation (4). Glycogen synthase is known to have two forms; the unphosphorylated and most active form, synthase-a, and the phosphorylated glucose-6-phosphate-dependent form, synthase-b. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Glycogen antibody, anti-Glycogen synthase 1 (muscle) antibody, anti-Glycogen synthase 1 antibody, anti-Glycogen synthase1 antibody, anti-GSY antibody, anti-GYS 1 antibody, anti-GYS antibody, anti-GYS1 antibody, anti-Starchsynthase muscle antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Browner MF, et al. Proc Nat Acad Sci 86:1443-1447, 1989. 2. Skurat A, et al. Diabetes Mellitus, pp 213-222. 1996. 3. Hardy TA, et al. J Biol Chem 268:23799-23805, 1993. 4. Skurat AV, et al. J Biol Chem 269:25534-25542, 1994. |
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