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| Catalog Code: | NB110-57005 |
| Product Name: | GluR1 Antibody |
| Product Description: | Rabbit Monoclonal anti-GluR1 (E308) |
| Clone: | E308 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues near N-terminus of human Glutamate receptor 1 was used as immunogen. |
| Cross Reactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Background: | Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry 1:50, immunoprecipitation 1:30, Western Blot 1:1000, |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-GPRC1A antibody, anti-GRM 1 antibody, anti-GRM1 alpha antibody, anti-GRM1 antibody, anti-GRM1A antibody, anti-Metabotropic glutamate receptor 1 antibody, anti-mGlu1 antibody, anti-mGluR1 alpha antibody, anti-mGluR1 antibody, anti-mGluR1A antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Potier, M.C., et al. The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. DNA Seq. 2: 211-8 (1992). 2. Puckett, C., et al. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. Proc. Nat. Acad. Sci. USA 88: 7557-61 (1991). 3. Gregor, P., et al. Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans. Proc. Nat. Acad. Sci. USA 90: 3053-3057 (1993). |
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