| request information: |
|
| Catalog Code: | NB110-57001 |
| Product Name: | Gab2 Antibody |
| Product Description: | Rabbit Monoclonal anti-Gab2 (EP369Y) |
| Clone: | EP369Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in human Gab2 was used as immunogen. This antibody is predicted to detect the splice isoform 2 based on sequence homology. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:500ICC: 1:50Flow Cytometry: 1:20IP: 1:50 |
| Background: | Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-GAB 2 antibody, anti-Grb 2 associated binder 2 antibody, anti-GRB 2 associated binding protein 2 antibody, anti-Grb2 associated binder 2 antibody, anti-GRB2 associated binder 2 pp100 antibody, anti-GRB2 associated binding protein 2 antibody, anti-KIAA0571 antibody, anti-pp100 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Zhao, C.; Yu, D.-H.; Shen, R.; Feng, G.-S. : J. Biol. Chem. 274: 19649-19654, 1999. 2. Weiss A, Littman DR: Cell 76:263, 1994 3. Holgado-Madruga, M., Moscatello, D. K., Emlet, D. R., Dieterich, R., and Wong, A. J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12419-12424 4. Gu H, Pratt JC, Burakoff SJ, Neel B. Mol Cell. 1998;2:729-740 5. Nishida K, Yoshida Y, Itoh M, et al. Blood. 1999;93:1809-1816 |
order or
more information: | company product webpage |
|
|