| CatalogCode: | NB110-56974 |
| ProductName: | Etk/Bmx Antibody |
| Product Description: | Rabbit Monoclonal anti-Etk/Bmx (Y396) |
| Clone: | Y396 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide corresponding to residues in the pleckstrin homology domain of human BMX. |
| Specificity: | This antibody recognises BMX. |
| CrossReactivity: | This species reacts with the human, mouse and rat proteins. Other species have not yet been tested. |
| Packaging: | 0.1 ml IgG purified Rabbit ascites. |
| Uses: | This antibody is useful for Immunoprecipitation and Western Blot (Detects a band of approximately 75 kDa predicted molecular weight: 78 kDa). |
| Background: | Etk (epithelial and endothelial tyrosine kinase) is a member of the TEC family of non-receptor protein tyrosine kinase which includes Btk, Itk and TEC. Etk is composed of a pleckstrin domain, an SH3 and SH2 domain and a catalytic kinase domain (1). Etk is implicated in cell adhesion, migration, proliferation, survival as well as signal transduction (2). In PCA, Etk activation by IL-6 is mediated by PI3-K (3). It as also been shown in TNF-induced angiogenesis, TNF activates Etk through TNFR2 (4). Additionally, in the AR pathway, ETtk, FAK and Src form a complex. FAK activates Src which in turn activates Etk by phosphorylating Etk tyrosine residue 566 (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Constituents: 40% Glycerol, 0.05% BSA, 50mM Tris glycine, 150mM Sodium chloride, pH 7.4. |
| ListPrice: | 325 |
| AppSummary: | IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Bone marrow tyrosine kinase gene in chromosome X protein antibody, anti-Cytoplasmic tyrosine protein kinase BMX antibody, anti-Epithelial and endothelial tyrosine kinase antibody, anti-ETK antibody, anti-NKT38 antibody, anti-NTK 38 antibody, anti-Protein tyrosine kinase BMX antibody, anti-PSCTK 2 antibody, anti-PSCTK 3 antibody, anti-PSCTK2 antibody, anti-PSCTK3 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Chen, R., O. Kim, M. Li, X. Xiong, J. L. Guan, H. J. Kung, H. Chen, Y. Shimizu, and Y. Qiu. 2001. Nat. Cell Biol. 3:439-444 2. Qiu, Y., and H. J. Kung. 2000. Oncogene 19:5651-5661 3. Yun Qiu, Dan Robinson, Tom G. Pretlow, and Hsing-Jien Kung, Cell Biology, Vol. 95, Issue 7, 3644-3649, March 31, 1998 4. Shi Pan, Ping An, Rong Zhang, Xiangrong He, Guoyong Yin, and Wang Min, Molecular and Cellular Biology, November 2002, p. 7512-7523, Vol. 22, No. 21. 5. Lee LF, Guan J, Qiu Y, Kung HJ. Mol Cell Biol. 2001 December; 21(24): 8385-8397 |
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