| CatalogCode: | NB110-56969 |
| ProductName: | Phospho ERK1(pT202/pY204) / ERK2(pT185/pY187) Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho ERK1(pT202/pY204) / ERK2(pT185/pY187) (E337) [Thr202/Tyr204+Thr185/Tyr187] |
| Clone: | E337 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic phospho-peptide corresponding to residues surrounding Thr202 and Tyr204 of human ERK1 was used as immunogen. The antibody only detects ERK1 phosphorylated on Threonine 202 and Tyrosine 204, or ERK2 phosphorylated on Threonine 185 and Tyrosine 187. |
| CrossReactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:500 IHC: 1:50 ICC: 1:250 |
| Background: | Extra cellular signal-regulated kinases Erk1 (p44 MAPK) and Erk2 (p42 MAPK) Serine/Threonine proteine kinase are part of a subfamily of mitogen-activated protein kinases that participate in diverse cellular functions, including the regulation of cell growth, differentiation, apoptosis and signal transduction (1,2,3) The simultaneous tyrosine/threonine phosphorylation of ERK1 and ERK2 results in their activation. Although ERK1and ERK2 resemble one another closely in sequence and are activated by similar pathways, they appearto have different tissue distributions(4) and show differential phosphorylation of potential intracellular substrates(5) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-ERK 2 antibody, ERT1 antibody, ERT2 antibody, Extracellular signal regulated kinase 1 antibody, Extracellular signal regulated kinase 2 antibody, HS44KDAP antibody, HUMKER1A antibody, Insulin stimulated MAP2 kinase antibody MAP kinase 1 antibody, MAP kinase 2 antibody, MAPK 1 antibody, MAPK 2 antibody, MAPK 3 antibody, MAPK1 antibody, MAPK2 antibody, MAPK3 antibody, MGC20180 antibody, Microtubule associated protein 2 kinase antibody, Mitogen activated protein kinase 1 antibody, Mitogen activated protein kinase 2 antibody, Mitogen activated protein kinase 3 antibody, p38 antibody, p40 antibody, p41 antibody, p41mapk antibody, p42 MAPK antibody, p42MAPK antibody, p44 ERK1 antibody, p44 MAPK antibody, p44ERK1 antibody, p44MAPK antibody, PRKM 1 antibody, PRKM 2 antibody, PRKM 3 antibody, PRKM1 antibody, PRKM2 antibody, PRKM3 antibody, Protein kinase mitogen activated 1 antibody, Protein kinase mitogen activated 2 antibody, Protein kinase mitogen activated 3 antibody, Protein tyrosine kinase ERK 2 antibody antibody antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Charest, D.L, et al. Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. Mol Cell Biol. 13: 4679-90 (1993). 2. Marshall, C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185 (1995). 3. Brott, B. K., Alessandrini, A., Largaespada, D. A., Copeland, N. G., Jenkins, N. A., Crews, C. M., and Ercikson, R. L. (1993) Cell Growth Differ. 4, 921-929 4. Boulton T. G. and Cobb M. H. (1991) Identification of multiple extracellular signal-regulated kinases (ERK5) with antipeptideantibodies. Cell Regul. 2, 357-371. |
| Phosphorylated: | Thr202/Tyr204+Thr185/Tyr187 |
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