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| Catalog Code: | NB110-56967 |
| Product Name: | ErbB3/HER3 (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-ErbB3/HER3 (C-term) (E186) |
| Clone: | E186 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to C-terminal residues of human c-erbB3 was used as immunogen. |
| Cross Reactivity: | Reacts in Human and Rat. Does not react in Mouse. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:500IP: 1:40 |
| Background: | ErbB3/Her3 is a member of the ErbB/EGF receptor protein tyrosine kinase family (1,2). Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases (3). Phosphorylation sites in the carboxy-terminal tail mediate downstream signaling pathways. While ErbB3 is highly expressed in many cancer cells (4), ErbB3 may work together with other Erb members in tumorogenesis and proliferation (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu(-), Rt, |
| Alternate Names: | anti-c erbB 3 antibody, anti-c erbB3 antibody, anti-ERBB3 antibody, anti-ERBB3 protein antibody, anti-erbB3 S antibody, anti-Glial growth factor receptor antibody, anti-HER 3 antibody, anti-HER3 antibody, anti-MDA BF 1 antibody, anti-MGC88033 antibody, anti-p180 ErbB3 antibody, anti-p45 sErbB3 antibody, anti-p85 sErbB3 antibody, anti-Receptor tyrosine protein kinase erbB 3 antibody, anti-Receptor tyrosine protein kinase erbB3 antibody, anti-Tyrosine kinase type cell surface receptor HER3 antibody, anti-v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody, anti-v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody, anti-v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Katoh, M., et al. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. Biochem Biophys Res Commun. 192: 1189-97 (1993). 2. Kraus, M.H., et al. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 86: 9193-7 (1989). 3. Guy, P.M., et al. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 91: 8132-8136 (1994). 4. Sithanandam, G., et al. Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway. Carcinogenesis 24: 1581-1592 (2003). 5. Alimandi, M., et al. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene 10: 1813-21 (1995). |
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