| CatalogCode: | NB110-56958 |
| ProductName: | Epithelial Antigen (Ep-CAM) (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-Epithelial Antigen (Ep-CAM) (C-term) (E144) |
| Clone: | E144 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide corresponding to residues in the C-terminus of Human EpCAM. |
| Specificity: | A synthetic peptide corresponding to residues in C-terminus (cytoplasmic domain) of human Ep-CAM was used as immunogen. |
| CrossReactivity: | Reacts in Human, Mouse, and Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Background: | Epithelial cell adhesion molecule (Ep-CAM) is a monomeric membrane glycoprotein that is expressed on virtually all epithelial cell membranes and on a variety of epithelial carcinomas (1-3). Ep-CAM is overexpressed in a variety of human carcinomas and is, therefore, a potential therapeutic target for human solid tumors (4). Ep-CAM contains an extracellular domain with two epidermal growth factor-like repeats, followed by a cysteine-poor region, which are necessary for the adhesion properties of the molecule (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Adenocarcinoma associated antigen antibody, anti-CD326 antibody, anti-CD326 antigen antibody, anti-Cell surface glycoprotein Trop 1 antibody, anti-CO17 1A antibody, anti-EGP antibody, anti-EGP40 antibody, anti-Ep CAM antibody, anti-Epithelial cell surface antigen antibody, anti-Epithelial cellular adhesion molecule antibody, anti-Epithelial glycoprotein antibody, anti-GA733 2 antibody, anti-hEGP 2 antibody, anti-KS 1/4 antigen antibody, anti-KSA antibody, anti-Lymphocyte antigen 74 antibody, anti-M1S2 antibody, anti-M4S1 antibody, anti-Major gastrointestinal tumor associated protein GA733 2 antibody, anti-MIC18 antibody, anti-MK 1 antibody, anti-TACSTD1 antibody, anti-TROP1 antibody, anti-Tumor associated calcium signal transducer 1 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Tomita, Y., et al. Molecular identification of a human carcinoma-associated glycoprotein antigen recognized by mouse monoclonal antibody FU-MK-1. J. Cancer Res. 91: 231-238 (2000). 2. Trebak, M., et al. Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion. J. Biol. Chem. 276: 2299-2309 (2001). 3. Simon, B., et al. Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein. Proc Natl Acad Sci U S A. 87: 2755-9 (1990). 4. Szala, S., et al. Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2. Proc Natl Acad Sci U S A. 87: 3542-6 (1990). 5. Balzar, M., et al. Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions. Mol. Cell. Biol. 21: 2570-2580 (2001). |
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