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| Catalog Code: | NB110-56956 |
| Product Name: | EMTK/ITK/TSK (N-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-EMTK/ITK/TSK (N-term) (Y401) |
| Clone: | Y401 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in the N-term of human Emtk/Itk/Tsk was used as immunogen. |
| Cross Reactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1,000-5,000 IHC: 1:250-500 Flow Cytometry: 1:80 IP: 1:50 |
| Background: | Emtk/Itk/Tsk is a member of the Tec family of Protein Tyrosine Kinase (PTK) expressed in T, NK, and mast cells (1). Structurally, Emtk/Itk/Tsk possesses a tyrosine kinase (TK), a pleckstrin homology (PH) and a TEC homology domain. It also contains both SRC homology 2 (SH2) and a SRC homology 3 (SH3) domains (2). It lacks as well the amino-terminal myristylation signal and the negative autoregulatory phosphorylation site present in all members of the Src family of PTKs (3). Additionally, the Src tyrosine kinase LCK is required for Emtk/Itk/Tsk activation and recruitment by CD28 (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-EMT antibody, anti-Homolog of mouse T cell itk/tsk antibody, anti-IL2 inducible T cell kinase antibody, anti-Kinase EMT antibody, anti-LYK antibody, anti-MGC126257 antibody, anti-MGC126258 antibody, anti-PSCTK 2 antibody, anti-PSCTK2 antibody, anti-T cell specific kinase antibody, anti-TSK antibody, anti-Tyrosine protein kinase antibody, anti-Tyrosine protein kinase ITK/TSK antibody, anti-Tyrosine protein kinase Lyk antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Gibson, S., B. Leung, J. A. Squire, M. Hill, N. Arima, P. Goss, D. Hogg, G. B. Mills. 1993. Blood 82:1561 2. Yamada, N., Y. Kawakami, H. Kimura, H. Fukamachi, G. Baier, A. Altman, T. Kato, Y. Inagaki, T. Kawakami. 1993. Biochem. Biophys. Res. Commun. 192:231 3. Desiderio, S., J. D. Siliciano. 1994. Chem. Immunol. 59:191 4. August, A., S. Gibson, Y. Kawakami, T. Kawakami, G. B. Mills, B. Dupont. 1994. Proc. Natl. Acad. Sci. USA 91:9347 |
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