| CatalogCode: | NB110-56933 |
| ProductName: | Dynamin-1 Antibody |
| Product Description: | Rabbit Monoclonal anti-Dynamin-1 (EP772Y) |
| Clone: | EP772Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues on human Dynamin-1 was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated Dynamin-1. |
| CrossReactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5000 - 20,000 ICC: 1:50 IP: 1:50 |
| Background: | The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IP, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-DNM 1 antibody, anti-DNM1 antibody, anti-Dynamin antibody, anti-Dynamin1 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Sontag JM, et al. J Biol Chem 269(6):4547-54, 1994. 2. Sweitzer SM, et al. Cell 93(6):1021-9, 1998. 3. Marks B, et al. Nature 410(6825):231-5, 2001. |
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