| CatalogCode: | NB110-56925 |
| ProductName: | DAP-1 Antibody |
| Product Description: | Rabbit Monoclonal anti-DAP-1 (E59) |
| Clone: | E59 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to C-terminus of human DAP-1 was used as immunogen. |
| CrossReactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:10,000 IHC: 1:100-1:250 ICC: 1:250 IP: 1:50 |
| Background: | Death associated protein 1 (DAP-1) is a 15-kDa protein that functions as a positive mediator of cell death initiated by interferon (IFN-) gamma (1,2). DAP-1 is proline rich and possesses one SH3 binding motif, as well as several consensus protein kinase phosphorylation sites (1). It is localized to the cytoplasm, but the detailed mechanism of its pro-apoptotic function is unclear. DAP-1 and DAP kinase, a unique, 160-kDa calmodulin-dependent serine/threonine kinase, are both unique candidates for positive mediators of programmed cell death induced by IFN-gamma (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-DAP 1 antibody, anti-DAP antibody, anti-Death Associated Protein 1 antibody, anti-MGC99796 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Deiss, L.P., et al. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9: 15-30 (1995). 2. Levy-Strumpf, N. and A. Kimchi. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. Oncogene 17: 3331-3340 (1998). 3. Cohen, O. and A. Kimchi. DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer. Cell Death Differ. 8: 6-15 (2001). |
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