| CatalogCode: | NB110-56914 |
| ProductName: | Cytokeratin 19 (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-Cytokeratin 19 (C-term) (EP1580Y) |
| Clone: | EP1580Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human CK-19 was used as an immunogen |
| CrossReactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:1,000,000 IHC: 1:250 - 500 ICC: 1:250 - 500 FC: 1:100 IP: 1:60 |
| Background: | Cytokeratin polypeptide 19 (CK19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia (1). Cytokeratins 8 and 19 concentrate at costameres of striated muscle and copurify with the dystrophin-glycoprotein complex, perhaps through the interaction of the cytokeratins with the actin-binding domain of dystrophin. Studies in COS-7 cells and in vitro showed that dystrophin binds directly and specifically to K19. Results show that dystrophin interacts through its ABD with CK19 specifically and are consistent with the idea that cytokeratins associate with dystrophin at the sarcolemma of striated muscle (2). CK19 is synthesized mainly in embryonic and adult simple epithelia, but has also been found in stratified epithelia as well. CK19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filaments, implying that regulation of its expression is different from other keratin-encoding genes (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Zhou X, et al. J Biol Chem 274(18):12861-6, 1999. 2. Stone MR, et al. Mol Biol Cell 16(9):4280-93, 2005. 3. Lussier M, et al. Gene 95(2):203-13, 1990. |
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