| CatalogCode: | NB110-56903 |
| ProductName: | Cyclin D3 Antibody |
| Product Description: | Rabbit Monoclonal anti-Cyclin D3 (EP463E) |
| Clone: | EP463E |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to a residue near the C-term of human Cyclin D3 was used as an immunogen. |
| CrossReactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5000 ICC: 1:100 - 250 FC: 1:30 |
| Background: | Cyclin D3 is a member of Cyclin D family which mediates cell cycle progression through the G1 phase. Cyclin D family binds and activates cyclin-dependent kinases 4 and 6 (CDK4, CDK6), which regulates the phosphorylation of retinoblastoma (Rb) protein, p107, and p130 (1). Cyclin D3, similar to cyclin D1 and D2, regulates the initial G1 to S transition by inhibiting Rb and activating E2F proteins (2). Cyclin D3 expression has been linked to inhibition of granulocyte differentiation and activation of various transcription factors, such as transcription factor 5 (3, 4). Overexpression of cyclin D3 is associated with poor clinical outcome in diffuse large B-cell lymphoma cases (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl, 40% Glycerol, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BS |
| ListPrice: | 325 |
| AppSummary: | FACS, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Sarruf D, et al. MCB, 25(22):9985-9995, 1995. 2. Dyson N, et al. Genes Dev. 12:2245-2262, 1998. 3. Liu W, et al. Biochem. Biophys. Res. Commun. 321:954-960, 2004. 4. Kato JY, et al. PNAS 90:11513-11517, 1993. 5. Filipits M, et al. Clin. Can. Res. 8:729-733, 2002. |
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