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| Catalog Code: | NB110-56902 |
| Product Name: | Cyclin D1 Antibody |
| Product Description: | Rabbit Monoclonal anti-Cyclin D1 (SP4) |
| Clone: | SP4 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide from C-terminus of human cyclin D1. |
| Cross Reactivity: | Reacts in Human, Mouse, and Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5000 IHC: 1:100 IP: 1:20 |
| Background: | Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7). |
| Storage: | Store at 4C. Do not freeze |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Tissue culture supernatant with 0.05% BSA. |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-B cell ccl/lymphoma 1 antibody, anti-B cell leukemia 1 antibody, anti-BCL1 antibody, anti-BCL1 oncogene antibody, anti-CCND 1 antibody, anti-CCND1 antibody, anti-CCND1 protein antibody, anti-CCND1/IGHG1 fusion gene antibody, anti-D11S287E antibody, anti-G1/S specific cyclin D1 antibody, anti-PRAD1 antibody, anti-PRAD1 oncogene antibody, anti-Parathyroid adenomatosis 1 antibody, anti-U21B31 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.1% sodium azide |
| General References: | 1. Inaba et al. Genomics 13:565-574, 1992. 2. Sherr CJ Canc Res 60:3689-3695, 2000. 3. Baldin et al. Genes Dev 7:812-821, 1993. 4. Bala S, Peltomaki P Cancer Res 61:6042-6045, 1999. 5. Motokura T, Arnold A Genes Chrom. Canc. 7:89-95, 1993. 6. Wang et al. Cancer Treat Res 119:217-237, 2004. 7. Neumeister et al. Mol Biol Cell 14:2005-2015. |
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