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| Catalog Code: | NB110-56901 |
| Product Name: | Cyclin D1 Antibody |
| Product Description: | Rabbit Monoclonal anti-Cyclin D1 (EP272Y) |
| Clone: | EP272Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide corresponding to residues near the N-terminus (Human) |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human Cyclin D1 was used as immunogen |
| Cross Reactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:1,000 ICC: 1:50-100 IP: 1:50 |
| Background: | Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4-5). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (6). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (7-8). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation , Western Blot , Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-B cell ccl/lymphoma 1 antibody, anti-B cell leukemia 1 antibody, anti-BCL1 antibody, anti-BCL1 oncogene antibody, anti-CCND 1 antibody, anti-CCND1 antibody, anti-CCND1 protein antibody, anti-CCND1/IGHG1 fusion gene antibody, anti-D11S287E antibody, anti-G1/S specific cyclin D1 antibody, anti-Parathyroid adenomatosis 1 antibody, anti-PRAD1 antibody, anti-PRAD1 oncogene antibody, anti-U21B31 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Inaba et al. Genomics 13: 565-574, 1992. 2. Sherr CJ 2000 The Pezcoller Lecture: Canc Res 60:3689-3695 3. Baldin et al. 1993 Genes Dev 7:812-821 4. Wang et al. Carcinogenesis 23:257-264 5. Bala S, Peltomaki P 2001 Cancer Res 61:6042-6045 6. Motokura T, Arnold A 1993 Genes Chrom. Canc. 7:89-95 7. Wang et al. 2004 Cancer Treat Res 119:217-237 8. Neumeister et al. Mol Biol Cell 14:2005-2015 |
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