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| Catalog Code: | NB110-55703 |
| Product Name: | CD5 Antibody |
| Product Description: | Rabbit Monoclonal anti-CD5 (SP19) |
| Clone: | SP19 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide from the intracellular region of CD5. |
| Cross Reactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB; 1:500IHC: 1:50-1:100 |
| Background: | CD5 (Lymphocyte antigen T1/Leu-1) is a transmembrane glycoprotein which has been implicated as a receptor in the regulation of T-cell proliferation (1). CD5 is part of the scavenger receptor cysteine-rich (SRCR) family group B and it is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5+ while the follicle center cell lymphomas are CD5. A ligand for CD72/LYB-2, CD5 has been linked to negative regulation of T cell and B cell receptors signaling (2). |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Tissue culture supernatant with 0.05% BSA. |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-CD 5 antibody, anti-CD5 antigen antibody, anti-CD5 molecule antibody, anti-LEU 1 antibody, anti-LEU1 antibody, anti-Ly12 antibody, anti-LyA antibody, anti-Lymphocyte Antigen CD5 antibody, anti-Lymphocyte antigen T1/Leu 1 antibody, anti-Lymphocyte glycoprotein T1/Leu1 antibody, anti-T cell surface glycoprotein CD5 antibody, anti-T1 antibody, anti-p56 62 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.1% sodium azide |
| General References: | 1. Spertini F et al. Journal of Immunology, 146(1):47-52, 1991. 2. Perez-Villar JJ et al. Mol Cell Biol, 19(4):2903-2912, 1999. |
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