| CatalogCode: | NB110-55692 |
| ProductName: | CD22 Phospho (pY807) Antibody |
| Product Description: | Rabbit Monoclonal anti-CD22 Phospho (pY807) (Y505) [Tyr807] |
| Clone: | Y505 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic phospho-peptide corresponding to residues surrounding Tyrosine 807 of human CD22 was used as immunogen. The antibody will detect CD22 phosphorylation on Tyrosine 807. This antibody is predicted to detect splice isoforms 2 based on sequence homology. |
| CrossReactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:2,000 |
| Background: | CD22, a negative regulator of B cell signaling, belongs to the sialoadhesin family of receptors that preferentially binds to á2-6-linked sialic acid on glycoproteins (1-2). CD22 is known to interact with the B cell antigen receptor (BCR) (3) and the tyrosine phosphatase SHP1. Tyrosine phosphorylation of CD22 leads to the recruitment of multiple intracellular Src homology 2 (SH2) domain-containing effector molecules, including phospholipase C and Syk, which are important for triggering Ca2+ influx, as well as PI 3-kinase and Grb2 (4-5). Phosphorylation of Tyrosine 807 is involved in the binding of Syk. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-B cell receptor CD22 precursor antibody, anti-B lymphocyte cell adhesion molecule antibody, anti-BL CAM antibody, anti-BLCAM antibody, anti-CD 22 antibody, anti-CD22 antigen antibody, anti-CD22 molecule antibody, anti-CD22 protein antibody, anti-Leu14 antibody, anti-Lyb8 antibody, anti-MGC130020 antibody, anti-SIGLEC 2 antibody, anti-SIGLEC2 antibody, anti-Sialic acid binding immunoglobulin like lectin 2 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Wilson, G. L.; Najfeld, V.; Kozlow, E.; Menniger, J.; Ward, D.; Kehrl, J. H.: J. Immun. 150: 5013-5024, 1993. 2. Nitschke, L., H. Floyd, P. R. Crocker. 2001. Scand. J. Immunol. 53:227 3. Tedder, T. F., J. Tuscano, S. Sato, J. H. Kehrl. 1997. Annu. Rev. Immunol. 15:481 4. Yohannan, J., J. Wienands, K. M. Coggeshall, L. B. Justement. 1999. J. Biol. Chem. 274:18769 5. Otipoby, K. L., K. E. Draves, E. A. Clark. 2001. J. Biol. Chem. 276:44315. |
| Phosphorylated: | Tyr807 |
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more information: | company product webpage |
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