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| Catalog Code: | NB110-55677 |
| Product Name: | CCR7/CKR7 Antibody |
| Product Description: | Rabbit Monoclonal anti-CCR7/CKR7 (E75) |
| Clone: | E75 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in loop-3 extracellular domain of human C-C chemokine receptor type 7 was used as immunogen. The antibody does not cross-react with other CKR family members. Predicted to cross-react with pig and bovine based on sequence homology. |
| Cross Reactivity: | Reacts in Human, Mouse, and Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:500Flow Cytometry: 1:20 |
| Background: | CCR7, or C-C chemokine receptor type 7, is a G protein-coupled, seven-transmembrane domain receptor protein. Originally identified as the EBV-induced gene-1 (1), CCR7 was later found to be the receptor for the chemokines CCL21 (SLC, 6Ckine, Exodus-2) (3) and CCL19 (MIP-3â, Exodus-3, ELC) (4). CCR7 is expressed in lymphoid tissues and activated B and T lymphocytes (2). It is up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7 (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-BLR 2 antibody, anti-BLR2 antibody, anti-C C chemokine receptor type 7 antibody, anti-C C CKR 7 antibody, anti-CC chemokine receptor type 7 antibody, anti-CC CKR 7 antibody, anti-CCCKR7 antibody, anti-CCR 7 antibody, anti-CD 197 antibody, anti-CD197 antibody, anti-CD197 antigen antibody, anti-CDW197 antibody, anti-Chemokine C C motif receptor 7 antibody, anti-CMKBR7 antibody, anti-EBI 1 antibody, anti-EBI1 antibody, anti-EBV Induced G Protein Coupled Receptor 1 antibody, anti-EVI 1 antibody, anti-EVI1 antibody, anti-Lymphocyte Specific G Protein Coupled Peptide Receptor antibody, anti-MIP 3 beta receptor antibody, anti-MIP3 Beta Receptor antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Schweickart, V. L., et al. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 23: 643-50 (1994). 2. Birkenbach, M., et al. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67: 2209-20 (1993). 3. Yoshida, R., et al. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. J. Biol. Chem. 273: 7118-22 (1998). 4. Yoshida, R., et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 272: 13803-9 (1997). |
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