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| Catalog Code: | NB110-55674 |
| Product Name: | CCR2/CKR2 (N-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-CCR2/CKR2 (N-term) (E68) |
| Clone: | E68 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to the N-terminal residues of the human C-C chemokine receptor type 2 was used as immunogen. The antibody does not cross-react with other CKR family members. |
| Cross Reactivity: | Reacts in Human and Mouse. Does not react in Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | IHC: 1:100ICC: 1:100Flow Cytometry: 1:25IP: 1:50 |
| Background: | CCR2, C-C chemokine receptor type 2, is a G protein-coupled, seven-transmembrane domain receptor protein. It has been found to be a monocyte chemoattractant protein 1 (MCP-1)-specific receptor (1,2). Activation of the CCR2b isoform by MCP-1 binding has been shown to trigger intracelluluar Ca2+ flux and activation of the Jak/Stat pathway (3). A variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors (4), making elucidating their specific functions important for more fully describing the process of HIV infection. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis , immunohistochemistry , immunoprecipitation , Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt(-), |
| Alternate Names: | anti-C C chemokine receptor type 2 antibody, anti-C C CKR 2 antibody, anti-CC chemokine receptor type 2 antibody, anti-CC CKR 2 antibody, anti-CCCKR2 antibody, anti-CCR 2 antibody, anti-CCR1L antibody, anti-CCR2A antibody, anti-CCR2B antibody, anti-CCR5L antibody, anti-CD192 antibody, anti-CD192 antigen antibody, anti-Chemokine C C motif receptor 2 antibody, anti-Chemokine CC Motif Receptor 2 antibody, anti-CKR 2 antibody, anti-CKR2 antibody, anti-CKR2A antibody, anti-CKR2B antibody, anti-CMKBR2 antibody, anti-MCP 1 R antibody, anti-MCP1 RECEPTOR antibody, anti-MCP1R antibody, anti-Monocyte chemoattractant protein 1 receptor antibody, anti-Monocyte Chemotactic Protein 1 Receptor antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Charo, I.F., et al. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A. 91: 2752-6 (1994). 2. Wong, L.M., et al. Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. J. Biol. Chem. 272: 1038-45 (1997). 3. Mellado, M., et al. The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J. Immunol. 161: 805-13 (1998). 4. Doranz, B.J., et al. A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the â-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors. Cell 85: 1149-1158 (1996). |
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