| CatalogCode: | | NB110-55671 |
| ProductName: | | Cbl Antibody |
| Product Description: | | Rabbit Monoclonal anti-Cbl (YE315) |
| Clone: | | YE315 |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues in the central region of human Cbl was used as immunogen. Predicted to cross-react with chicken, based on sequence homology. |
| CrossReactivity: | | Reacts in Human and Rat. Does not react in Mouse. Not tested in other species. |
| Packaging: | | 0.1 ml |
| Uses: | | WB: 1:500IHC: 1:50ICC: 1:100 |
| Background: | | c-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | IHC, WB, ICC |
| SpeciesSummary: | | Hu, Mu(-), Rt |
| ALTnames: | | anti-C CBL antibody, anti-Cas-Br-M (murine) ecotropic retroviral transforming sequence antibody, anti-Casitas B lineage lymphoma proto oncogene antibody, anti-CBL 2 antibody, anti-CBL2 antibody, anti-E3 ubiquitin protein ligase CBL antibody, anti-Oncogene CBL2 antibody, anti-Proto oncogene c CBL antibody, anti-RING finger protein 55 antibody, anti-RNF55 antibody, anti-Signal transduction protein CBL antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Langdon, W. Y., et al. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc. Natl. Acad. Sci. USA 86: 1168-72 (1989). 2. Blake, T. J., et al. The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J. 12: 2017-26 (1993). 3. Joazeiro, C. A., et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286: 309-12 (1999). 4. Galisteo, M. L., et al. Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J. Biol. Chem. 270: 20242-5 (1995). |
| more information: | | company product webpage |
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