| request information: |
|
| Catalog Code: | NB110-55667 |
| Product Name: | Caspase-8 (N-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-Caspase-8 (N-term) (E6) |
| Clone: | E6 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to N-terminal residues of human Caspase-8 was used as immunogen. The antibody should recognize all splice isoforms of Caspase-8. |
| Cross Reactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:3,000IHC: 1:100Flow Cytometry: 1:50IP: 1:50 |
| Background: | Caspase-8 (MACH/FLICE/Mch5) is a member of a family of cysteine-requiring aspartate proteases that participate in the intracellular signaling cascade leading to apoptosis, or programmed cell death (1-4). Caspase-8 is recruited to death-inducing signaling complex (DISC) CD95 (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) and is subsequently activated by proteolytic cleavage into two residues, p10 and p18 (1-4). Active caspase-8, the first in the caspase signaling cascade, signals downstream caspases to eventually induce apoptosis. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-Apoptotic cysteine protease antibody, anti-Apoptotic protease Mch 5 antibody, anti-CAP 4 antibody, anti-CAP4 antibody, anti-CASP 8 antibody, anti-G16196 antibody, anti-CASP8 antibody, anti-Caspase8 antibody, anti-CED 3 antibody, anti-FADD homologous ICE/CED 3 like protease antibody, anti-FADD Homologous ICE/CED3 Like Protease antibody, anti-FADD Like ICE antibody, anti-FLICE antibody, anti-ICE like apoptotic protease 5 antibody, anti-MACH antibody, anti-MCH 5 antibody, anti-MCH5 antibody, anti-MGC78473 antibody, anti-MORT1 associated CED 3 homolog antibody, anti-MORT1 associated CED3 homolog antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Muzio, M. et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827 (1996). 2. Boldin, M.P. et al. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death. Cell 85: 803-815 (1996). 3. Srinivasula, S.M. et al. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U S A 93(25): 14486-91 (1996). |
order or
more information: | company product webpage |
|