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| Catalog Code: | NB110-55652 |
| Product Name: | CaMKII Antibody |
| Product Description: | Rabbit Monoclonal anti-CaMKII (EP1829Y) |
| Clone: | EP1829Y |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide corresponding to residues on human CaMKII |
| Specificity: | A synthetic peptide corresponding to residues on human CaMKII was used as an immunogen. |
| Cross Reactivity: | Reacts in Human, Mouse, and Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:20,000 IHC: 1:100 - 250 ICC: 1:250 - 500 FC: 1:80 IP: 1:50 |
| Background: | Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis , immunohistochemistry , immunoprecipitation , Western Blot , Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-CAMK 2 antibody, anti-CAMK 2A antibody, anti-CAMK2 antibody, anti-CAMK2A antibody, anti-CAMKA antibody, anti-CaM kinase II alpha antibody, anti-CaM kinase II alpha chain antibody, anti-CaM kinase II alpha subunit antibody, anti-CaM kinase II antibody, anti-CaMK II alpha subunit antibody, anti-CaMK II antibody, anti-Calcium/calmodulin dependent protein kinase II alpha B subunit antibody, anti-Calcium/calmodulin dependent protein kinase II alpha antibody, anti-Calcium/calmodulin dependent protein kinase IIA antibody, anti-Calcium/calmodulin dependent protein kinase type II alpha chain antibody, anti-Calcium/calmodulin dependent protein kinase type II antibody, anti-KCC2A antibody, anti-KIAA0968 antibody, anti-Kinase CaMK2 alpha antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Krapivinsky G, et al. Neuron 43(4):563-74, 2004 2. Zhang J, et al. Biochem Biophys Res Commun 285(2): 229-34, 2001. |
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