| CatalogCode: | NB110-55650 |
| ProductName: | Calponin-1 (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-Calponin-1 (C-term) (EP798Y) |
| Clone: | EP798Y |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide corresponding to residues near the C-term of Calponin (Human). |
| Specificity: | A synthetic peptide corresponding to residues near the C-term of human Calponin was used as an immunogen. |
| CrossReactivity: | Reacts in Human, Mouse, and Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody works for IHC, WB, ICC and is unsuitable for IP. |
| Localization: | Cytoplasmic |
| Background: | Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-binding protein thought to be involved in regulation of actomyosin as well as the regulation or modulation of contraction (1). Calponin binds filamentous actin (F-actin) through two distinct sites ABS1 and ABS2, with an affinity in the low micromolar range (2) Immunoreactivity for calponin, along with alpha-smooth muscle actin and smooth muscle myosin heavy chains, confirms the known neoplastic myoepithelial component of adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. The consistently positive staining pattern in adenoid cystic carcinomas may be diagnostically useful in discriminating histologically similar but consistently negative polymorphous low-grade adenocarcinomas (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Basic calponin antibody, anti-CNN 1 antibody, anti-CNN1 antibody, anti-Calponin 1 antibody, anti-Calponin 1 basic smooth muscle antibody, anti-Calponin H1 smooth muscle antibody, anti-Calponin1 antibody, anti-Calponins basic antibody, anti-SMCC antibody, anti-Sm Calp antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Strasser P, et al. FEBS Lett. 330(1):13-8, 1993 2. Ferjani I, et al. FEBS Lett. 580(20):4801-6, 2006 3. Prasad AR, et al. Arch Pathol Lab Med. 123(9): 801-6, 1999 |
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