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| Catalog Code: | NB110-55649 |
| Product Name: | Calmodulin Antibody |
| Product Description: | Rabbit Monoclonal anti-Calmodulin (EP799Y) |
| Clone: | EP799Y |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide: CDGDGQVNYEEFVQMMTAK, corresponding to C terminal amino acids 132-149 of Human Calmodulin BLAST 'CDGDGQVNYEEFVQMMTAK' |
| Specificity: | A synthetic peptide corresponding to residues in the C-terminus of human Calmodulin was used as immunogen. |
| Cross Reactivity: | Reacts in Human, Mouse, and Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Background: | Calmoduin (CaM) is a calcium modulator protein and a transducer of calcium signals (1-2). Upon calcium binding, calmodulin undergoes conformational changes and binds and modulates a diverse array of proteins. Calcium-bound CaM (Ca2+-CaM) can assume a variety of shapes depending on the target (3). Ca2+-CaM binds many kinases, phosphatases, signaling proteins, and structural proteins affecting a wide variety of processes including neurotransmitter release, muscle contraction, metabolism, apoptosis, inflammation, membrane protein organization, and cytoskeleton movement (2, 4-5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis 1:50 , immunohistochemistry 1:250-500 , immunoprecipitation 1:50, Western Blot 1:1,000-5,000 , Immunocytochemistry 1:100-250, |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-CALM 1 antibody, anti-CALM 2 antibody, anti-CALM 3 antibody, anti-CALM antibody, anti-CALM1 antibody, anti-CALM2 antibody, anti-CALM3 antibody, anti-CALML2 antibody, anti-CAM 1 antibody, anti-CAM 2 antibody, anti-CAM 3 antibody, anti-CAM I antibody, anti-CAM1 antibody, anti-CAM2 antibody, anti-CAM3 antibody, anti-CAMB antibody, anti-CAMC antibody, anti-CAMI antibody, anti-CAMIII antibody, anti-CaM antibody, anti-Calmodulin 1 antibody, anti-Calmodulin1 antibody, anti-DD132 antibody, anti-PHKD antibody, anti-Phosphorylase kinase delta antibody, anti-Phosphorylase kinase delta subunit antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Sasagawa T, Ericsson LH, Walsh KA, Schreiber WE, Fischer EH, Titani K. Biochemistry. 1982 May 11;21(10):2565-9. 2. Eldik L.V. and Watterson,D.M. (1998) Academic Press, San Diego, CA 3. Finn B.E., Evenas,J., Drakenberg,T., Waltho,J.P., Thulin,E. and Forsen,S. (1995) Nat. Struct. Biol., 2, 777-783. 4. DeMaria C.D., Soong,T.W., Alseikhan,B.A., Alvania,R.S. and Yue,D.T. (2001) Nature, 411, 484-489. 5. Deisseroth K., Heist,E.K. and Tsien,R.W. (1998) Nature, 392, 198-202. |
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