| CatalogCode: | NB110-55648 |
| ProductName: | Caldesmon Antibody |
| Product Description: | Rabbit Monoclonal anti-Caldesmon (EP789Y) |
| Clone: | EP789Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the N-term of human Caldesmon was used as immunogen. |
| CrossReactivity: | Reacts in Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:1000 IHC: 1:250 - 500 ICC: 1:250 - 500 IP: 1:50 |
| Background: | Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin (1,2). Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and actin-binding region at the C-terminus and a myosin-binding domain at the N-terminus (3). Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-CAD antibody, anti-CALD 1 antibody, anti-CALD1 antibody, anti-CDM antibody, anti-Caldesmon 1 Isoform 1 antibody, anti-Caldesmon 1 Isoform 2 antibody, anti-Caldesmon 1 Isoform 3 antibody, anti-Caldesmon 1 Isoform 4 antibody, anti-Caldesmon 1 Isoform 5 antibody, anti-Caldesmon 1 antibody, anti-Caldesmon1 antibody, anti-H CAD antibody, anti-HCAD antibody, anti-L CAD antibody, anti-LCAD antibody, anti-MGC21352 antibody, anti-NAG22 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Humphrey MB, et al. Gene 112:197-204, 1992. 2. Bryan J, et al. J Biol Chem 264:13873-13879, 1989. 3. Bryan J, et al. Ann N Y Acad Sci 599:100-110, 1990. 4. Fraser ID, et al. Biochem 36:5483-5492, 1997. |
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