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| Catalog Code: | NB110-55568 |
| Product Name: | c-Jun (C-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-c-Jun (C-term) (EP693Y) |
| Clone: | EP693Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to the C-terminal residues of human c-Jun was used as immunogen. |
| Cross Reactivity: | Human. Does not react in Mouse or Rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1,000-5,000IHC: 1:100-250ICC: 1:100-250IP: 1:50 |
| Background: | c-Jun is a component of the transcription factor AP-1 (1). The transcriptional activity of c-Jun is regulated by phosphorylation at serines 63 and 73 (1,2). Extracellular signals, including growth factors, transforming oncoproteins and UV light, stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription (3,4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-AP1 antibody, anti-Activator Protein 1 antibody, anti-Enhancer Binding Protein AP1 antibody, anti-JUN antibody, anti-JUN protein antibody, anti-JUNC antibody, anti-Jun Activation Domain Binding Protein antibody, anti-Jun oncogene antibody, anti-Proto oncogene cJun antibody, anti-Transcription Factor AP1 antibody, anti-V jun avian sarcoma virus 17 oncogene homolog antibody, anti-p39 antibody, anti-vJun Avian Sarcoma Virus 17 Oncogene Homolog antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Bohmann, D., et al. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238: 1386-92 (1987). 2. Smeal, T., et al. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354: 494-496 (1991). 3. Derijard, B., et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037 (1994). 4. Kyriakis, J.M., et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369: 156-160 (1994). |
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