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| Catalog Code: | NB110-55567 |
| Product Name: | c-Cbl Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho c-Cbl (pY731) (EP973Y) [Tyr731] |
| Clone: | EP973Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic phospho-peptide corresponding to residues surrounding Tyr731 of human Cbl was used as immunogen. The antibody detects Cbl phosphorylated on Tyrosine 731. |
| Cross Reactivity: | Human, Mouse, Rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:2000IP: 1:50 |
| Background: | c-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| Phosphorylated: | Tyr731 |
| General References: | 1. Langdon, WY, et al. Proc. Natl. Acad. Sci. 86:1168-72, 1989. 2. Blake, TJ, et al. EMBO J. 12:2017-26, 1993. 3. Joazeiro, CA, et al. Science 286:309-12, 1999. 4. Galisteo, ML, et al. J. Biol. Chem. 270: 20242-5, 1995. |
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